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Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (94%), Zebrafish (82%), Xenopus laevis (82%), Chicken (87%), Bovine (91%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: APAF1-interacting protein; APIP; CG129; dJ179L10.2; hAPIP; Methylthioribulose-1-phosphate dehydratase; MTRu-1-P dehydratase; probable methylthioribulose-1-phosphate dehydratase
基因别名: APIP; APIP2; CGI-29; CGI29; hAPIP; MMRP19
UniProt ID: (Human) Q96GX9
Entrez Gene ID: (Human) 51074
分子生物学功能: dehydratase lyase metabolite interconversion enzyme