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Invitrogen
ARAP1 Polyclonal Antibody
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Product Details
PA5-142073
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-AFTADPLSLLRNV.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is expected to recognise isoform a (NP_056057.2), isoform c (NP_001035207.1) and isoform d (NP_001128662.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: arap1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; centaurin, delta 2; Centaurin-delta-2; Cnt-d2
Gene Aliases: 2410002L19Rik; ARAP1; CENTD2; KIAA0782; mKIAA0782
UniProt ID: (Human) Q96P48, (Mouse) Q4LDD4
Entrez Gene ID: (Human) 116985, (Mouse) 69710
positive regulation of receptor recycling
signal transduction
regulation of cell shape
actin filament reorganization involved in cell cycle
positive regulation of GTPase activity
positive regulation of epidermal growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
regulation of cellular component movement
positive regulation of filopodium assembly
negative regulation of stress fiber assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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