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Invitrogen
ARAP1 Polyclonal Antibody
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产品信息
PA5-21742
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human ARAP1. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: A431, H1299, HeLa, HepG2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; centaurin, delta 2; Centaurin-delta-2; Cnt-d2
基因别名: ARAP1; CENTD2; KIAA0782
UniProt ID: (Human) Q96P48
Entrez Gene ID: (Human) 116985
positive regulation of receptor recycling
signal transduction
regulation of cell shape
actin filament reorganization involved in cell cycle
positive regulation of GTPase activity
positive regulation of epidermal growth factor receptor signaling pathway
regulation of small GTPase mediated signal transduction
regulation of cellular component movement
positive regulation of filopodium assembly
negative regulation of stress fiber assembly
