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Invitrogen
ARAP1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-67101
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
20 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SLPSTIAAPHP MDGPPGGSTP VTPVIKAGWL DKNPPQGSYI YQKRWVRLDT DHLRYFDSNK DAYSKRFISV ACISHVAAIG DQKFEVITNN RTFAFRAESD VERK
Highest antigen sequence identity to the following orthologs - mouse 80%, rat 82%.
靶标信息
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1; ArfGAP with RhoGAP domain, ANK repeat and PH domain-containing protein 1; centaurin-delta-2; KIAA0782
基因别名: CENTD2; cnt-d2
UniProt ID: (Human) Q96P48
Entrez Gene ID: (Human) 116985
positive regulation of receptor recycling
regulation of receptor internalization
actin filament organization
signal transduction
regulation of cell shape
regulation of endocytosis
regulation of cell projection organization
regulation of actin cytoskeleton organization
positive regulation of GTPase activity
regulation of bone resorption
photoreceptor cell maintenance
positive regulation of phagocytosis
regulation of small GTPase mediated signal transduction
positive regulation of cellular component organization
positive regulation of filopodium assembly
negative regulation of stress fiber assembly
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Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
