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Invitrogen
ARAP2 Polyclonal Antibody
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产品信息
PA5-23326
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 1670-1704 of human ARAP2.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
The amino acid sequence used as immunogen is 87% homologous in Mouse and Rat, 81% homologous in Canine.
靶标信息
ARAP2 also known as Centaurin-delta-1 is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3, 4, 5-trisphosphate-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) binding and can be activated by phosphatidylinositol-3, 4-bisphosphate (PtdIns(3, 4, 5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arf and Rho GAP adapter protein 2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; centaurin; centaurin, delta 1; Centaurin-delta-1; Cnt-d1; Protein PARX
基因别名: ARAP2; CENTD1; KIAA0580; PARX
UniProt ID: (Human) Q8WZ64
Entrez Gene ID: (Human) 116984
