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Invitrogen
ARAP3 Polyclonal Antibody
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FIGURE: 1 / 5
ARAP3 Antibody (PA5-60158) in IHC (P)
Immunohistochemistry analysis of ARAP3 in human duodenum. Samples were incubated with ARAP3 polyclonal antibody (Product # PA5-60158). Shows strong membranous positivity in endothelial cells and weak cytoplasmic membranous positivity in glandular cells.
Product Details
PA5-60158
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ARAP3. Recombinant protein control fragment (Product #RP-90738).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MPNSIYFGLD SRGRAQAAQD KAPDSSQISA PTPALRPTTG TVHIMDPGCL YYGVQPVGTP GAPDRRESRG VCQGRAEHRL SRQDLEARED AGYASLELPG DSTLLSPTLE TEETSDDLIS PYASFSF
Highest antigen sequence identity to the following orthologs: Mouse - 80%, Rat - 80%.
Target Information
Ubiquitin is a conserved 76 amino acid polypeptide and can affect proteasomal degradation of the protein it is bound to, or mediate interactions with other proteins related to post-translational modifications. The degradation of cellular regulatory proteins by the Uubiquitin pathway is important as it controls the cellular growth and proliferation. Ubiquitin-dependent proteolysis occurs after a covalent attachment of the peptide to a lysine residue of a protein, which involves three enzymatic reactions: E1, E2 and E3. The first reaction involves ubiquitin-activating enzyme. The third reaction uses enzyme ubiquitin ligase (E3) to transfer the activated ubiquitin from E2 to a lysine residue on a protein, or directly transfers the ubiquitin from E2 to the substrate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arf and Rho GAP adapter protein 3; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3; centaurin; centaurin, delta 3; Centaurin-delta-3; Cnt-d3; FLJ21065; phosphoinositide binding protein; PtdIns(3,4,5)P3-binding protein
Gene Aliases: ARAP3; CENTD3; DRAG1
UniProt ID: (Human) Q8WWN8
Entrez Gene ID: (Human) 64411
cytoskeleton organization
signal transduction
regulation of cell shape
vesicle-mediated transport
negative regulation of cell migration
negative regulation of Rac protein signal transduction
negative regulation of Rho protein signal transduction
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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