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Invitrogen
ARHGAP20 Polyclonal Antibody
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FIGURE: 1 / 3
ARHGAP20 Antibody (PA5-104102) in IHC (P)
Immunohistochemistry analysis of ARHGAP20 in mouse brain tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ARHGAP20 polyclonal antibody (Product # PA5-104102) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-104102
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ARHGAP20(Accession Q9P2F6), corresponding to amino acid residues Q503-E553.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total RHG20.
Target Information
ARHGAP20 is a potent GTPase-activating protein (GAP) and convert Rho-type GTPases into an inactive GDP-bound state. It contains a pleckstrin homology (PH) domain, a Ras-associating domain, a Rho-GAP domain and two Annexin-like (ANXL) repeats. ARHGAP20 is a direct downstream target of Rap1 in the neurite outgrowth while it's over expression leads to inactivation of Rho for promoting the neurite outgrowth in a Rap1-dependent manner. ARHGAP20 is a tumor suppressor gene and is inactivated by deletion in breast cancer and also by chromosomal translocation in B-cell chronic lymphocytic leukemia. Reports suggest that it may take part in rearrangements of the cytoskeleton and cell signaling events that occur during spermatogenesis. It is expressed predominantly in human brain, liver, ovary and spinal cord while low expression is found in lymph nodes and fetal liver.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: RA and RhoGAP domain containing protein; RA and RhoGAP domain-containing protein; RARhoGAP; rho GTPase activating protein 20 variant 2; Rho GTPase-activating protein 20; Rho-type GTPase-activating protein 20; RhoGTPase activating protein
Gene Aliases: 6530403F17Rik; A530023E23Rik; ARHGAP20; KIAA1391; mKIAA1391; RARHOGAP
UniProt ID: (Human) Q9P2F6, (Rat) Q6REY9, (Mouse) Q6IFT4
Entrez Gene ID: (Human) 57569, (Rat) 367085, (Mouse) 244867
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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