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Antibody detects endogenous levels of total RHG24.
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Down-regulated in nephrectomized rat kidney #2; Filamin-A-associated RhoGAP; FilGAP; p73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho GTPase-activating protein 24; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88
基因别名: 0610025G21Rik; ARHGAP24; DR-NR#2; FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72
UniProt ID: (Human) Q8N264, (Mouse) Q8C4V1, (Rat) Q5U2Z7
Entrez Gene ID: (Human) 83478, (Mouse) 231532, (Rat) 305156