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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Immunogen sequence: ERDPSVLYQY QPHGKRQSSV TVVSQYDNLE DYHSLPQHQR GVFGGGGMGT YVPPGFPHPQ SRTYATALGQ GAFLPAELSL QHPETQIHAE
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 88%.
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: brain-specific Rho GTP-ase-activating protein; brain-specific Rho GTPase-activating protein; GAB-associated CDC42; GAB-associated Cdc42/Rac GTPase-activating protein; GTPase regulator interacting with TrkA; GTPase-activating protein for Cdc42 and Rac1; PX-RICS; rac GTPase activating protein; Rho family GAP; GC-GAP; rho-type GTPase-activating protein 32; rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling; rhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
基因别名: GC-GAP; GRIT; p200RhoGAP; p250GAP; PX-RICS; RICS
UniProt ID: (Human) A7KAX9
Entrez Gene ID: (Human) 9743