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Invitrogen
ARHGEF12 Polyclonal Antibody
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产品信息
PA5-101847
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ARHGEF12(Accession Q9NZN5), corresponding to amino acid residues K583-P633.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ARHGEF12.
靶标信息
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: leukemia-associated Rho guanine nucleotide exchange factor; leukemia-associated Rho guanine-nucleotide exchange factor; Leukemia-associated RhoGEF; Rho guanine nucleotide exchange factor (GEF) 12; Rho guanine nucleotide exchange factor 12
基因别名: 2310014B11Rik; ARHGEF12; AU019857; KIAA0382; LARG; mKIAA0382; PRO2792
UniProt ID: (Human) Q9NZN5
Entrez Gene ID: (Human) 23365, (Rat) 367072, (Mouse) 69632
G-protein coupled receptor signaling pathway
regulation of Rho protein signal transduction
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
biological_process
termination of G-protein coupled receptor signaling pathway
