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Invitrogen
ARL6IP6 Polyclonal Antibody
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ARL6IP6 Antibody (PA5-144044) in ICC/IF
Immunocytochemistry analysis of ARL6IP6 in Caco-2 cells. Enzyme antigen retrieval was performed using IHC enzyme antigen retrieval reagent for 15 mins. The cells were blocked with 10% goat serum. Samples were then incubated in ARL6IP6 Polyclonal antibody (Product # PA5-144044) using a dilution of 5 μg/mL. DyLight®488 Conjugated Goat Anti-Rabbit IgG was used as secondary antibody at 1:100 dilution and incubated for 30 minutes at 37°C. The section was counterstained with DAPI. Visualize using a fluorescence microscope and filter sets appropr... View More
产品信息
PA5-144044
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence of human ARL6IP6 (VARDLRAEFSAGA) (aa 51-63).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human 293T whole cell, human Caco-2 whole cell, rat lung tissue, mouse testis tissue, mouse lung tissue. IHC: human bladder epithelial carcinoma tissue, human bladder epithelial carcinoma tissue, human gastric cancer tissue, human lung cancer tissue, human ovarian cancer tissue, human metaplasia of squamous cells of the renal pelvis tissue. ICC/IF: Caco-2 cell. Flow: HEPA1-6 cell, HL-60 cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The ARL6IP6 gene has been identified as a novel candidate gene associated with a syndromic form of Cutis Marmorata Telangiectatica Congenita (CMTC), suggesting that ischemic stroke or transient ischemic attacks (TIA) might represent the mild end of the phenotypic spectrum, with autosomal recessive CMTC as the severe manifestation. The ARL6IP6 influences the susceptibility to these conditions, highlighting its importance in vascular and dermatological syndromes. Mutations in ARL6IP6 can lead to a range of phenotypic outcomes, from mild ischemic events to serious congenital skin disorders, emphasizing the need for deeper genetic and phenotypic exploration to understand its role in human pathology. Moreover, the gene is potentially involved in intracellular trafficking processes that are crucial for proper cellular function, which can be impacted by genetic variations, leading to clinical manifestations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ADP-ribosylation factor GTPase 6 interacting protein 6; ADP-ribosylation factor like GTPase 6 interacting protein 6; ADP-ribosylation factor-like 6 interacting protein 6; ADP-ribosylation factor-like protein 6-interacting protein 6; ADP-ribosylation-like factor 6 interacting protein 6; ADP-ribosylation-like factor 6-interacting protein 6; aip-6; ARL-6-interacting protein 6; Phosphonoformate immuno-associated protein 1; regulated by phosphonoformate
基因别名: 2310057C01Rik; 2610529A11Rik; AIP-6; AIP6; ARL6IP6; PFAAP1
UniProt ID: (Human) Q8N6S5, (Mouse) Q8BH07, (Rat) Q68FV2
Entrez Gene ID: (Human) 151188, (Mouse) 65103, (Rat) 499798
