Search Thermo Fisher Scientific
Sequence of this protein is as follows: NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHIPLPRPQ SAAPETDVPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDYDDQLC
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: arrestin 3; Arrestin beta-2; arrestin, beta 2; Beta-arrestin-2; Non-visual arrestin-3
基因别名: ARB2; ARR2; ARRB2; BARR2; BARRES
UniProt ID: (Human) P32121, (Rat) P29067
Entrez Gene ID: (Human) 409, (Rat) 25388