Abnova

ARRB2 Monoclonal Antibody (4D2)

查看其他13个beta-Arrestin 2抗体

问题与答案

问题与答案

问题与答案

抗体检测数据 (1)

ARRB2 Antibody in Western Blot (WB)

ARRB2 Antibody in Western Blot (WB)

图: 1 / 1

ARRB2 Antibody (H00000409-M06J) in WB

ARRB2 monoclonal antibody (M06J), clone 4D2. Western Blot analysis of ARRB2 expression in PC-12.

ARRB2 Antibody in Western Blot (WB)

Product Image Gallery

ARRB2 Antibody in Western Blot (WB) — ARRB2 monoclonal antibody (M06J), clone 4D2. Western Blot analysis of ARRB2 expression in PC-12.

Immunogen image

ARRB2 Monoclonal Antibody (4D2)

Immunogen Image ARRB2 Monoclonal Antibody (4D2)

产品信息

H00000409-M06J

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1-5 µg/mL

-

免疫细胞化学 (ICC/IF)

10-100 µg/mL

-

酶联免疫吸附实验 (ELISA)

10 µg/mL

-

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG2a, kappa

分类

Monoclonal

类型

Antibody

克隆号

4D2

抗原

ARRB2 (AAH07427.1, 300 a.a. approximately 409 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.43 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

no preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Product may be used with Western Blot (Cell lysate).

Immunogen sequence: NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHIPLPRPQ SAAPETDVPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDYDDQLC

Cell culture grade monoclonal antibodies are obtained by purifying "hybridoma culture medium" which completely eliminates any contamination of mice. They have high affinity, high purity, and no contamination.

靶标信息

Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

篇参考文献 (0)

您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。

引用该产品

生物信息学

蛋白别名: arrestin 3; Arrestin beta-2; arrestin, beta 2; Beta-arrestin-2; Non-visual arrestin-3

查看更多收起

基因别名: ARB2; ARR2; ARRB2; BARR2; BARRES

查看更多收起

UniProt ID: (Human) P32121, (Rat) P29067

查看更多收起

Entrez Gene ID: (Human) 409, (Rat) 25388

查看更多收起

G-protein coupled receptor binding receptor binding protein binding enzyme binding protein domain specific binding ubiquitin protein ligase binding alpha-1A adrenergic receptor binding alpha-1B adrenergic receptor binding angiotensin receptor binding type 1 angiotensin receptor binding D1 dopamine receptor binding follicle-stimulating hormone receptor binding type 2A serotonin receptor binding platelet activating factor receptor binding protein complex binding protein complex scaffold protein kinase B binding mitogen-activated protein kinase binding 14-3-3 protein binding clathrin binding scaffold/adaptor protein

G-protein coupled receptor internalization desensitization of G-protein coupled receptor protein signaling pathway by arrestin positive regulation of receptor internalization transcription from RNA polymerase II promoter transforming growth factor beta receptor signaling pathway dopamine receptor signaling pathway brain development adult walking behavior protein transport protein ubiquitination platelet activation negative regulation of protein ubiquitination positive regulation of protein ubiquitination receptor internalization negative regulation of NF-kappaB transcription factor activity positive regulation of synaptic transmission, dopaminergic negative regulation of interleukin-1 beta production negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production positive regulation of peptidyl-serine phosphorylation negative regulation of toll-like receptor signaling pathway negative regulation of GTPase activity negative regulation of smooth muscle cell apoptotic process follicle-stimulating hormone signaling pathway negative regulation of cysteine-type endopeptidase activity involved in apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process negative regulation of natural killer cell mediated cytotoxicity positive regulation of peptidyl-tyrosine phosphorylation detection of temperature stimulus involved in sensory perception of pain positive regulation of protein kinase B signaling negative regulation of protein kinase B signaling positive regulation of calcium ion transport Wnt signaling pathway, planar cell polarity pathway cell chemotaxis regulation of androgen receptor signaling pathway positive regulation of ERK1 and ERK2 cascade negative regulation of release of cytochrome c from mitochondria chemical synaptic transmission, postsynaptic positive regulation of DNA biosynthetic process regulation of protein phosphorylation positive regulation of protein phosphorylation endocytosis G-protein coupled receptor signaling pathway regulation of G-protein coupled receptor protein signaling pathway regulation of cAMP biosynthetic process regulation of cAMP catabolic process