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Abnova
ARS2 Polyclonal Antibody, MaxPab™
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产品信息
H00051593-B02P
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ARS2 (NP_877952, 1 a.a. approximately 796 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Cell lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MRRDWDEHSS DPYHSGYEMP YAGGGGGPTY GPPQPWGHPD VHIMQHHVLP IQARLGSIAE IDLGVPPPVM KTFKEFLLSL DDSVDETEAV KRYNDYKLDF RRQQMQDFFL AHKDEEWFRS KYHPDEVGKR RQEARGALQN RLRVFLSLME TGWFDNLLLD IDKADAIVKM LDAAVIKMEG GTENDLRILE QEEEEEQAGK PGEPSKKEEG RAGAGLGDGE RKTNDKDEKK EDGKQAENDS SNDDKTKKSE GDGDKEEKKE DSEKEAKKSS KKRNRKHSGD DSFDEGSVSE SESESESGQA EEEKEEAEAL KEKEKPKEEE WEKPKDAAGL ECKPRPLHKT CSLFMRNIAP NISRAEIISL CKRYPGFMRV ALSEPQPERR FFRRGWVTFD RSVNIKEICW NLQNIRLREC ELSPGVNRDL TRRVRNINGI TQHKQIVRND IKLAAKLIHT LDDRTQLWAS EPGTPPLPTS LPSQNPILKN ITDYLIEEVS AEEEELLGSS GGAPPEEPPK EGNPAEINVE RDEKLIKVLD KLLLYLRIVH SLDYYNTCEY PNEDEMPNRC GIIHVRGPMP PNRISHGEVL EWQKTFEEKL TPLLSVRESL SEEEAQKMGR KDPEQEVEKF VTSNTQELGK DKWLCPLSGK KFKGPEFVRK HIFNKHAEKI EEVKKEVAFF NNFLTDAKRP ALPEIKPAQP PGPAQILPPG LTPGLPYPHQ TPQGLMPYGQ PRPPILGYGA GAVRPAVPTG GPPYPHAPYG AGRGNYDAFR GQGGYPGKPR NRMVRGDPRA IVEYRDLDAP DDVDFF
靶标信息
Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: arsenate resistance protein 2; arsenate resistance protein ARS2; arsenite resistance protein; Arsenite-resistance protein 2; Serrate RNA effector molecule homolog
基因别名: ARS2; ASR2; serrate; SRRT
UniProt ID: (Human) Q9BXP5
Entrez Gene ID: (Human) 51593
