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Invitrogen
ASAHL Polyclonal Antibody
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FIGURE: 1 / 3
ASAHL Antibody (PA5-69357) in IHC (P)
Immunohistochemical analysis of ASAHL in paraffin-embedded human liver tissue. Sample was probed with a ASAHL polyclonal antibody (Product # PA5-69357) at a dilution of 1:100. Detection was performed with a donkey anti-Rabbit Cy3 secondary antibody at a dilution of 1:200. Images were taken at 20x magnification with an exposure time of 0.5-2.0 seconds.
Product Details
PA5-69357
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the middle region of human ASAHL
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 100%; Guinea Pig: 92%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 93%; Rat: 100%
Target Information
N-acylsphingosine amidohydrolase-like 1 (ASAHL), commonly referred to as acid ceramidase-like protein, is a gene located on human chromosome 22q13.31. ASAHL encodes a protein that functions as a ceramidase, responsible for hydrolyzing ceramide into sphingosine and fatty acid, which are pivotal for cell signaling pathways that regulate cell growth, differentiation, and apoptosis. Though similar to acid ceramidase, ASAHL's specific biological role and tissue distribution remain active research areas, suggesting potential involvement in lipid metabolism and cellular homeostasis. Dysregulation of ceramidase activity, including ASAHL, is linked to various diseases, such as cancer, neurodegenerative disorders, and metabolic syndromes, due to the crucial role of sphingolipid signaling in these conditions. The gene's activity may influence ceramide levels within cells, impacting susceptibility to apoptosis and other cell fate decisions, highlighting its importance in pathophysiological contexts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acid ceramidase-like protein; Acylsphingosine deacylase NAAA; ASAH-like protein; N-acylethanolamine-hydrolyzing acid amidase; N-acylsphingosine amidohydrolase-like
Gene Aliases: ASAHL; NAAA; PLT
UniProt ID: (Human) Q02083
Entrez Gene ID: (Human) 27163
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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