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Invitrogen
ASAP2 Polyclonal Antibody
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产品信息
PA5-144952
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: WRLLHEDLDE SDDDMDEKLQ PSPNRREDRP ISFYQLGSNQ LQSNAVSLAR DAANLAKDKQ RAFMPSILQN ETY
Antigen sequence identity: Mouse 89%; Rat 88%
靶标信息
ASAP2 is a multidomain protein belonging to the beta family with two ANK repeats, an Arf-GAP domain, a PH domain and a SH3 domain. This protein localizes in the Golgi apparatus and also at the plasma membrane where it colocalizes with protein tyrosine kinase 2-beta (PYK2) and forms a stable complex with PYK2 in vivo. ASAP2 is tyrosine phosphorylated by activated PYK2. It functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. ASAP2 activates the small GTPases ARF1, ARF5 and ARF6 and regulates the formation of post-Golgi vesicles and modulates constitutive secretion. It modulates phagocytosis mediated by Fc gamma receptor and ARF6. Usually detected in heart, brain, placenta, kidney, monocytes and pancreas, it is up-regulated during monocyte maturation. Multiple transcript variants encoding different isoforms have been found.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2; centaurin, beta 3; development and differentiation enhancing factor 2; Development and differentiation-enhancing factor 2; PAG3; PAP; PAPbeta; Paxillin-associated protein with ARF GAP activity 3; PYK2 C terminus-associated protein; Pyk2 C-terminus-associated protein
基因别名: AMAP2; ASAP2; CENTB3; DDEF2; KIAA0400; PAG3; PAP; Pap-alpha; SHAG1
UniProt ID: (Human) O43150
Entrez Gene ID: (Human) 8853
