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Invitrogen
ASIP Polyclonal Antibody
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产品信息
PA5-71446
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
synthetic peptide directed towards the middle region of human ASIP
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: agouti signaling protein, nonagouti homolog; Agouti switch protein; Agouti-signaling protein; ASP; nonagouti homolog
基因别名: AGSW; AGTI; AGTIL; ASIP; ASP; SHEP9
UniProt ID: (Human) P42127
Entrez Gene ID: (Human) 434
generation of precursor metabolites and energy
signal transduction
cell-cell signaling
adult feeding behavior
hormone-mediated signaling pathway
melanosome transport
melanosome organization
regulation of molecular function, epigenetic
melanin biosynthetic process
positive regulation of melanin biosynthetic process
genetic imprinting
