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Invitrogen
ASPM Polyclonal Antibody
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产品信息
PA5-67689
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthesized peptide derived from human ASPM.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Abnormal spindle protein homolog; Abnormal spindle-like microcephaly-associated protein; asp (abnormal spindle) homolog, microcephaly associated; Asp homolog
基因别名: ASP; ASPM; Calmbp1; MCPH5
UniProt ID: (Human) Q8IZT6
Entrez Gene ID: (Human) 259266
neuron migration
positive regulation of neuroblast proliferation
spindle organization
mitotic nuclear division
spermatogenesis
male gonad development
forebrain neuroblast division
cerebral cortex development
negative regulation of neuron differentiation
negative regulation of asymmetric cell division
oogenesis
developmental growth
regulation of meiotic cell cycle
spindle localization
maintenance of centrosome location
positive regulation of canonical Wnt signaling pathway
spindle assembly involved in meiosis
neuronal stem cell population maintenance
