Invitrogen

ATF4 Polyclonal Antibody

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说明书
实验方案
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ATF4 Polyclonal Antibody

产品信息

PA5-78832

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1-0.5 µg/mL
-

免疫组化（石蜡） (IHC (P))

0.5-1 µg/mL
-
产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence of human ATF4 (KELEKKNEALKERADSLAKEIQYLKDLIEEVRKARGKKRVP).
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

500 µg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 4mg trehalose

内含物

0.05mg sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2745948

产品详细信息

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: human SW620 whole cell, human Hela whole cell. IHC: human ovary cancer tissue, human prostatic cancer tissue.

靶标信息

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Activating transcription factor 4; ATF 4; ATF4 protein; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB 2; CREB-2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; OTTHUMP00000199130; tax-re; tax-responsive enhancer element B67; Tax-responsive enhancer element-binding protein 67; TaxREB67

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基因别名: ATF4; CREB-2; CREB2; TAXREB67; TXREB

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UniProt ID: (Human) P18848

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Entrez Gene ID: (Human) 468

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功能
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein C-terminus binding leucine zipper domain binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity DNA-binding transcription factor
参与通路
gluconeogenesis regulation of transcription, DNA-templated transcription from RNA polymerase II promoter cellular amino acid metabolic process gamma-aminobutyric acid signaling pathway positive regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of translational initiation in response to stress circadian regulation of gene expression cellular response to amino acid starvation cellular response to UV response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress PERK-mediated unfolded protein response cellular response to glucose starvation mRNA transcription from RNA polymerase II promoter positive regulation of apoptotic process negative regulation of potassium ion transport positive regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of oxidative stress-induced neuron death positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress response to manganese-induced endoplasmic reticulum stress
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