Invitrogen

ATG11 Monoclonal Antibody (7C2NB)

Name: ATG11 Monoclonal Antibody (7C2NB)
Brand: Invitrogen
SKU: MA5-62073

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

Immunogen image

Immunogen Image ATG11 Monoclonal Antibody (7C2NB)

产品信息

MA5-62073

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.5 µg/mL

产品规格

种属反应

Yeast

宿主/亚型

Mouse / IgM, lambda

分类

Monoclonal

类型

Antibody

克隆号

7C2NB

抗原

Partial recombinant protein made to an internal sequence of the S. cerevisiae ATG11 protein (between amino acids 50-250).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

IgM

保存液

PBS

内含物

0.05% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_3703051

靶标信息

ATG11 (Autophagy-Related Gene 11) is a key gene involved in the autophagy process, a cellular degradation and recycling system that is crucial for maintaining cellular homeostasis. Autophagy allows cells to break down and reuse damaged organelles, misfolded proteins, and other cellular debris, especially under conditions of stress or nutrient deprivation. ATG11 encodes a scaffold protein that plays a pivotal role in selective autophagy by facilitating the recruitment and organization of autophagy machinery components to the phagophore assembly site. It is particularly important in the selective degradation of specific organelles, such as peroxisomes (pexophagy) and mitochondria (mitophagy), as well as in the removal of protein aggregates. Dysfunction or mutations in ATG11 can disrupt autophagic processes, leading to the accumulation of cellular waste and contributing to various pathological conditions, including neurodegenerative diseases like Parkinson's and Alzheimer's, as well as certain cancers. Understanding the function and regulation of ATG11 is essential for developing therapeutic strategies aimed at enhancing autophagy to treat these diseases. Research into ATG11 continues to provide valuable insights into the mechanisms of selective autophagy and its broader implications for cellular health and disease management.

仅用于科研。不用于诊断过程。未经明确授权不得转售。