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Invitrogen
ATG14 Polyclonal Antibody
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ATG14 Antibody (PA5-87326) in WB
Western blot analysis of ATG14 in Lane 1: H1792 whole cell lysate (20 µg), Lane 2: HEK293T whole cell lysate (40 µg), Lane 3: HepG2 whole cell lysate (40 µg), Lane 4: C6 whole cell lysate (40 µg), Lane 5: AML-12 whole cell lysate (40 µg). Sample was incubated with ATG14 polyclonal antibody (Product # PA5-87326) using a 1:1000 dilution.
产品信息
PA5-87326
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombination protein, corresponding to amino acids 152-406 of Human ATG14.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
ATG14 (Autophagy related protein homolog 14) is encoded by the ATG14 gene and is located on chromosome 14 in humans. It is also known as ATG14L or BARKOR (Beclin 1-associated autophagy-related key regulator). Autophagy is an evolutionarily conserved process that involves recycling of misfolded cellular proteins and degradation of dysfunctional organelles. Autophagy is induced as a cellular response to nutrient stress which includes the formation of autophagosomes, fusion of these with the lysosome and formation of the autophagolysosome. The Class III PI3-Kinase, Vps34 and its interacting partner Beclin 1 have been shown to form a complex which specifically includes ATG 14 (type 1) or UVRAG (type 2). Atg 14 guides the type 1 complex to the preautophagosomal structure (PAS) and is critical for the initiation of autophagosome formation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATG14 autophagy related 14 homolog; Atg14-like protein; Atg14L; Autophagy-related protein 14-like protein; Bakor; Barkor; Beclin 1-associated autophagy-related key regulator; Beclin 1-Interacting protein; VATG14 autophagy related 14 homolog
基因别名: 4832427M01; ATG14; ATG14L; BARKOR; D14Ertd114e; D14Ertd436e; KIAA0831; RGD1304610
UniProt ID: (Human) Q6ZNE5, (Mouse) Q8CDJ3, (Rat) D4A4K3
Entrez Gene ID: (Human) 22863, (Mouse) 100504663, (Rat) 305831
autophagosome assembly
regulation of protein phosphorylation
negative regulation of protein phosphorylation
positive regulation of protein phosphorylation
endosome to lysosome transport
cellular response to starvation
positive regulation of autophagy
posttranscriptional regulation of gene expression
macroautophagy
cellular response to glucose starvation
positive regulation of phosphatidylinositol 3-kinase activity
regulation of protein complex stability
regulation of triglyceride metabolic process
mitophagy in response to mitochondrial depolarization
autophagy
mitophagy
biological_process
