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ATG8A-I/Autophagy-related protein 8A-I isoforms Polyclonal Antibody
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ATG8A-I/Autophagy-related protein 8A-I isoforms Antibody (AS14-2811) in WB
2 µg of respective recombinant Arabidopsis thaliana ATG 8 isoform, denatured at 95 C for 2 min. were separated on % SDS-PAGE and blotted 1 h to nitrocellulose (GE 10600003) using semi-dry transfer. Blots were blocked with 3% milk for 1 h at room temperature (RT) with agitation. Blot was incubated in the primary antibody at a dilution of 1:4 000 for 1 h at RT with agitation. The antibody solution was decante... View More
产品信息
AS14-2811
产品规格
种属反应
Plant
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Part of recombinant ATG8A from Arabidopsis thaliana.
偶联物
形式
Lyophilized
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Recombinant ATG8 A-I of Arabidopsis thaliana, Oryza sativa
靶标信息
ATG8A-I isoforms are plant autophagy related ubiquitin like proteins that tag membranes and cargo for formation and maturation of autophagosomes. After synthesis, each ATG8 isoform is processed by ATG4 to expose a C terminal glycine, then conjugated to phosphatidylethanolamine by the ATG7 ATG3 E1 E2 like system and the ATG12 ATG5 ATG16 complex, anchoring ATG8 to autophagic membranes. Different ATG8A I isoforms show selective binding to cargo receptors via AIM or LIR motifs and help mediate selective autophagy of organelles, protein aggregates, and signaling components during nutrient limitation, development, and stress. Their lipidation state serves as a marker of autophagic flux, and expression and activity are modulated by redox status, kinases, and hormone signaling. Perturbation of specific isoforms alters recycling efficiency, stress tolerance, and growth by reshaping degradation pathways and cellular homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG8a; ATG8a; autophagy-related protein 8A
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