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Invitrogen
ATGL Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-110189
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 45-257 of human PNPLA2 (NP_0651091)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1.24 mg/mL
规格
124 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: GASAGALTAT ALVTGVCLGE AGAKFIEVSK EARKRFLGPL HPSFNLVKII RSFLLKVLPA DSHEHASGRL GISLTRVSDG ENVIISHFNS KDELIQANVC SGFIPVYCGL IPPSLQGVRY VDGGISDNLP LYELKNTITV SPFSGESDIC PQDSSTNIHE LRVTNTSIQF NLRNLYRLSK ALFPPEPLVL REMCKQGYRD GLRFLQRNGL LNR
靶标信息
Lipolytic enzymes are required for mobilization of fatty acids from triglyceride stores in adipose tissue. Energy homeostasis is affected by dysfunctional lipolysis and may contribute to the pathogenesis of obesity and insulin resistance. Until recently, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. It is now thought that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. ATGL is highly expressed in adipose tissue of mice and humans. It exhibits high substrate specificity for triacylglycerol and is associated with lipid droplets. Inhibition of ATGL markedly decreases total adipose acyl-hydrolase activity. Thus, ATGL and HSL coordinately catabolize stored triglycerides in adipose tissue of mammals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: adipose triglyceride lipase; ATGL DESNUTRIN; calcium-independent phospholipase A2; calcium-independent phospholipase A2-zeta; desnutrin; DKFZp667M109; IPLA2 zeta; IPLA2-zeta; lipase; missense mutations at exon 2 causes amino acid substitution Leu56Arg; missense mutations at exon 5 causes amino acid substitution Ile193Phe; mutant patatin-like phospholipase domain containing 2; patatin like phospholipase domain containing 2; patatin-like phospholipase domain containing 2; patatin-like phospholipase domain-containing protein 2-like; PEDF R; pigment epithelium-derived factor; pigment epithelium-derived factor receptor; plpl; plpl2; PNPLA2; transport-secretion protein; transport-secretion protein 2.2; triglyceride hydrolase; TTS 2.2; TTS2.2; TTS; putative hydrolase; unnamed protein product
基因别名: 0610039C21Rik; 1110001C14Rik; ATGL; FP17548; iPLA2zeta; PEDF-R; RGD1309044; TTS-2.2; TTS2
UniProt ID: (Human) Q96AD5, (Mouse) Q8BJ56, (Rat) P0C548
Entrez Gene ID: (Human) 57104, (Mouse) 66853, (Rat) 361676
retinoid metabolic process
lipid metabolic process
diacylglycerol biosynthetic process
positive regulation of triglyceride catabolic process
lipid catabolic process
triglyceride catabolic process
lipid storage
lipid particle organization
cellular triglyceride homeostasis
retinol metabolic process
lipid homeostasis
lipid droplet fusion
lipid droplet disassembly
acylglycerol acyl-chain remodeling
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