Invitrogen

ATP1B1 Recombinant Rabbit Monoclonal Antibody (4M5T3)

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ATP1B1 Recombinant Rabbit Monoclonal Antibody (4M5T3)

产品信息

MA5-35647

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

免疫组化（石蜡） (IHC (P))

1:50-1:200
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

4M5T3

抗原

Synthetic peptide
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.04 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2849547

产品详细信息

Immunogen sequence: YNPNVLPVQC TGKRDEDKDK VGNVEYFGLG NSPGFPLQYY PYYGKLLQPK YLQPLLAVQF TNLTMDTEIR IECKAYGENI GYSEKDRFQG RFDVKIEVKS

靶标信息

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: adenosinetriphosphatase; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na+/K+ ATPase Beta; Na, K-ATPase beta-1 polypeptide; Na,K-ATPase beta 1 subunit; OTTHUMP00000032537; OTTHUMP00000032538; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1

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基因别名: ATP1B; ATP1B1; Atp4b; Atpb; Atpb-1; ATPBS; NKbeta1

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UniProt ID: (Human) P05026, (Rat) P07340, (Mouse) P14094

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Entrez Gene ID: (Human) 481, (Rat) 25650, (Mouse) 11931

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功能
ATPase activator activity sodium:potassium-exchanging ATPase activity protein binding ATP binding protein C-terminus binding drug binding ATPase activity MHC class II protein complex binding potassium ion binding sodium ion binding ATPase binding primary active transporter
参与通路
response to hypoxia positive regulation of defense response to virus by host cellular calcium ion homeostasis cellular sodium ion homeostasis cell adhesion potassium ion import establishment or maintenance of transmembrane electrochemical gradient regulation of gene expression regulation of cardiac muscle contraction by calcium ion signaling cellular potassium ion homeostasis positive regulation of ATPase activity ion transmembrane transport sodium ion export from cell protein transport into plasma membrane raft ATP metabolic process protein stabilization leukocyte migration relaxation of cardiac muscle cardiac muscle contraction protein localization to plasma membrane membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction ATP hydrolysis coupled transmembrane transport mitophagy in response to mitochondrial depolarization xenophagy positive regulation of potassium ion transmembrane transporter activity positive regulation of sodium ion export from cell positive regulation of calcium:sodium antiporter activity positive regulation of potassium ion import regulation of cardiac conduction potassium ion import across plasma membrane blastocyst development potassium ion transport sodium ion transport metal ion transport regulation of calcium ion transmembrane transport transport ion transport
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