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Invitrogen
ATP4A Polyclonal Antibody
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ATP4A Antibody (PA5149785) in IHC (P)
Immunohistochemistry analysis of ATP4A in paraffin-embedded Mouse Stomach tissue. Samples were incubated with ATP4A Polyclonal (Product # PA5149785) antibody using a dilution of 20 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
产品信息
PA5149785
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant ATPase, H+/K+ Exchanging Alpha Polypeptide (ATP4a) (Pro786-Cys1014)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
The ATP4A gene encodes the alpha subunit of the gastric H+/K+ ATPase, an enzyme crucial for gastric acid secretion in the stomach. This proton pump resides in the parietal cells of the gastric mucosa and is responsible for exchanging potassium ions (K+) for hydrogen ions (H+), effectively acidifying the stomach contents. ATP4A plays a significant role in maintaining the acidic environment necessary for digestion and defense against pathogens. The ATPase's activity is tightly regulated by various factors, including hormones like gastrin and histamine, to ensure optimal stomach function. Mutations in ATP4A can lead to disorders related to gastric acidity, such as hypochlorhydria (low stomach acid), which can impact digestion and absorption of nutrients. Understanding ATP4A's function and its regulatory mechanisms is essential for developing treatments for conditions like peptic ulcer disease and gastroesophageal reflux disease, where gastric acid secretion is disrupted.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase, H+/K+ exchanging, alpha polypeptide; ATPase, H+/K+ transporting, alpha polypeptide; Gastric H(+)/K(+) ATPase subunit alpha; gastric H+/K+ ATPase alpha subunit; gastric H,K-ATPase alpha subunit; gastric H,K-ATPase catalytic subunit; gastric hydrogen-potassium ATPase; H(+)-K(+)-ATPase alpha subunit; H+/K+-ATPase alpha; H+K+-transporting alpha 1; hydrogen/potassium-exchanging ATPase 4A; Potassium-transporting ATPase alpha chain 1; Proton pump
基因别名: ATP4A; ATP6A; Hka; Hkatpc
UniProt ID: (Human) P20648, (Mouse) Q64436
Entrez Gene ID: (Human) 495, (Rat) 24216, (Mouse) 11944
transport
cellular sodium ion homeostasis
potassium ion import
establishment or maintenance of transmembrane electrochemical gradient
ATP hydrolysis coupled proton transport
cellular potassium ion homeostasis
ion transmembrane transport
sodium ion export from cell
gastric acid secretion
potassium ion transport
metabolic process
regulation of proton transport
sodium ion transmembrane transport
response to drug
pH reduction
potassium ion transmembrane transport
hydrogen ion transmembrane transport
ion transport
sodium ion transport
proton transport
