NeoBiotechnologies

ATRX/RAD54 (Alpha Thalassemia Mental Retardation) Monoclonal Antibody (ATRX/7940)

Name: ATRX\/RAD54 (Alpha Thalassemia Mental Retardation) Monoclonal Antibody (ATRX\/7940)
Brand: NeoBiotechnologies
SKU: 546-MSM10-P0

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说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (2)

ATRX/RAD54 (Alpha Thalassemia Mental Retardation) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ATRX/RAD54 (Alpha Thalassemia Mental Retardation) Antibody (546-MSM10-P0) in IHC (P)

Formalin-fixed, paraffin-embedded human colon stained with ATRX Mouse Monoclonal Antibody (ATRX/7940). HIER: Tris/EDTA, pH9.0, 45 min. 2 °: HRP-polymer, 30 min. DAB, 5 min.

ATRX/RAD54 (Alpha Thalassemia Mental Retardation) Antibody in SDS-PAGE (SDS-PAGE)

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Immunogen image

Immunogen Image ATRX/RAD54 (Alpha Thalassemia Mental Retardation) Monoclonal Antibody (ATRX/7940)

产品信息

546-MSM10-P0

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

Assay-dependent

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG

分类

Monoclonal

类型

Antibody

克隆号

ATRX/7940

抗原

Recombinant full-length human ATRX protein

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS, pH 7.4, with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4°C, do not freeze

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

ATRX encodes a protein that contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); ATP-dependent helicase ATRX; DNA dependent ATPase and helicase; helicase 2; helicase 2, X-linked; mental retardation, X-linked 52; RP5-875J14.1; Transcriptional regulator ATRX; X-linked helicase II; X-linked nuclear protein; XNP; Zinc finger helicase; Znf-HX

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基因别名: ATR2; ATRX; JMS; MRX52; MRXHF1; RAD54; RAD54L; SFM1; SHS; XH2; XNP; ZNF-HX

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UniProt ID: (Human) P46100

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Entrez Gene ID: (Human) 546

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功能