Rockland

AXIN1 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
AXIN1 Polyclonal Antibody

Product Details

600-401-Z14

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

20 µg/mL
-

ELISA (ELISA)

1:10,000-1:20,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-AXIN1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 14 amino acid synthetic peptide near the C-terminus of human AXIN1.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; LA16c-314G4.3; MGC52315; Protein Fused; protein phosphatase 1, regulatory subunit 49; rAxin

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Gene Aliases: AI316800; AXIN; AXIN1; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49

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UniProt ID: (Human) O15169, (Rat) O70239, (Mouse) O35625

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Entrez Gene ID: (Human) 8312, (Rat) 79257, (Mouse) 12005

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Function(s)
signal transducer activity GTPase activator activity protein binding beta-catenin binding enzyme binding protein kinase binding receptor signaling complex scaffold activity ubiquitin protein ligase binding protein complex scaffold identical protein binding protein homodimerization activity SMAD binding armadillo repeat domain binding I-SMAD binding p53 binding receptor binding protein C-terminus binding protein domain specific binding protein self-association R-SMAD binding scaffold/adaptor protein
Process(es)
optic placode formation positive regulation of protein phosphorylation apoptotic process activation of JUN kinase activity determination of left/right symmetry cell death dorsal/ventral axis specification positive regulation of peptidyl-threonine phosphorylation Wnt signaling pathway forebrain anterior/posterior pattern specification Wnt-activated signaling pathway involved in forebrain neuron fate commitment negative regulation of Wnt signaling pathway olfactory placode formation cytoplasmic microtubule organization positive regulation of protein ubiquitination activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation negative regulation of transcription elongation from RNA polymerase II promoter regulation of catenin import into nucleus proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of GTPase activity cellular protein complex assembly negative regulation of fat cell differentiation positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of JNK cascade embryonic eye morphogenesis axial mesoderm formation positive regulation of ubiquitin-protein transferase activity muscle cell development canonical Wnt signaling pathway embryonic skeletal joint morphogenesis canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation cellular response to organic cyclic compound negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis positive regulation of canonical Wnt signaling pathway beta-catenin destruction complex assembly beta-catenin destruction complex disassembly positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein polyubiquitination in utero embryonic development regulation of protein phosphorylation nucleocytoplasmic transport sensory perception of sound adult walking behavior dorsal/ventral pattern formation hemoglobin metabolic process protein catabolic process positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process erythrocyte homeostasis post-anal tail morphogenesis termination of G-protein coupled receptor signaling pathway positive regulation of JUN kinase activity positive regulation of protein kinase activity axial mesoderm development neurological system process negative regulation of protein metabolic process protein homooligomerization genetic imprinting signal transduction multicellular organism development cell differentiation
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