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Invitrogen
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This antibody reacts with various forms of porcine acrosin (55, 53, 45 and 35 kDa), a typical serine proteinase with trypsin-like specificity. Acrosin is stored in the acrosome of undamaged spermatozoa.
This antibody will not cross-react with human, canine or bovine.
Immunocytochemistry: Membrane permeabilization (acetone) is essential.
ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: 53 kDa fucose-binding protein; Acrosin; acrosin precursor (EC 3.4.21.10); preproacrosin
基因别名: ACR
UniProt ID: (Pig) P08001
Entrez Gene ID: (Pig) 397098