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Invitrogen

Activin A Polyclonal Antibody

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2 篇参考文献
查看其他22个Activin A抗体

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产品信息

PA5-47004

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.1 µg/mL
-

免疫组化 (IHC)

-
查看2篇已发表文章 2篇已发表文章

免疫组化（石蜡） (IHC (P))

5-15 µg/mL
-

免疫细胞化学 (ICC/IF)

5-25 µg/mL
-

中和实验 (Neu)

2-6 µg/mL
-
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

CHO-derived recombinant human Activin A

偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

规格

100 µg

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 5% trehalose

内含物

No Preservative

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2609618

产品详细信息

Reconstitute at 0.2 mg/mL in sterile PBS.

Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.

靶标信息

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: activin A; activin beta-A chain; beta-A inhibin; erythroid differentiation factor; erythroid differentiation protein; erythroid differentiation protein precursor; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhba; inhibin beta A subunit; inhibin beta-A; inhibin beta-A-subunit precursor; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; unnamed protein product

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基因别名: EDF; FRP

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UniProt ID: (Human) P08476, (Mouse) Q04998, (Rat) P18331

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Entrez Gene ID: (Human) 3624, (Mouse) 16323, (Rat) 29200

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功能
receptor binding cytokine activity hormone activity protein binding growth factor activity peptide hormone binding identical protein binding macromolecular complex binding type II activin receptor binding protein sequestering activity
参与通路
ovarian follicle development mesoderm formation positive regulation of protein phosphorylation hair follicle development hematopoietic progenitor cell differentiation regulation of transcription from RNA polymerase II promoter lipid metabolic process steroid biosynthetic process autophagy transmembrane receptor protein serine/threonine kinase signaling pathway steroid metabolic process androgen metabolic process negative regulation of cell proliferation male gonad development gene expression positive regulation of gene expression cytokine-mediated signaling pathway striatal medium spiny neuron differentiation negative regulation of cell growth activin receptor signaling pathway negative regulation of activin receptor signaling pathway positive regulation of collagen biosynthetic process endodermal cell differentiation odontogenesis hemoglobin biosynthetic process progesterone secretion positive regulation of erythrocyte differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of transcription from RNA polymerase III promoter regulation of follicle-stimulating hormone secretion mesodermal cell differentiation cell development animal organ development system development positive regulation of protein metabolic process negative regulation of hair follicle development Sertoli cell differentiation palate development positive regulation of ovulation positive regulation of SMAD protein import into nucleus SMAD protein signal transduction cardiac fibroblast cell development eyelid development in camera-type eye testosterone biosynthetic process positive regulation of ERK1 and ERK2 cascade cellular response to follicle-stimulating hormone stimulus cellular response to cholesterol cellular response to hypoxia cellular response to oxygen-glucose deprivation GABAergic neuron differentiation extrinsic apoptotic signaling pathway androst-4-ene-3,17-dione biosynthetic process response to aldosterone cellular response to angiotensin negative regulation of G1/S transition of mitotic cell cycle positive regulation of extrinsic apoptotic signaling pathway in absence of ligand defense response cell surface receptor signaling pathway cell-cell signaling nervous system development response to wounding cell differentiation erythrocyte differentiation negative regulation of interferon-gamma production negative regulation of phosphorylation negative regulation of B cell differentiation negative regulation of macrophage differentiation positive regulation of follicle-stimulating hormone secretion negative regulation of follicle-stimulating hormone secretion
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