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Invitrogen
Activin A (Garetosmab Biosimilar) Recombinant Humanized mouse Monoclonal Antibody
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Activin A (Garetosmab Biosimilar) Antibody (MA5-42137) in SDS-PAGE
SDS-PAGE analysis of the recombinant Human INHBA protein expressed in CHO cells using a Activin A (Garetosmab Biosimilar) monoclonal antibody (Product # MA5-42137). R denotes the lane was run under reducing conditions. NR denotes the lane was run under non-reducing conditions.
产品信息
MA5-42137
产品规格
种属反应
Human
宿主/亚型
Artificial Control
/ IgG4, kappa
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
抗原
Human INHBA
偶联物
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Endotoxin level < 0.01EU/µg by LAL method
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.
靶标信息
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Activin beta-A chain; beta-A inhibin; EDF; erythroid differentiation factor; Erythroid differentiation protein; erythroid differentiation protein precursor; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin beta A subunit; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1; unnamed protein product
基因别名: EDF; FRP; INHBA
UniProt ID: (Human) P08476
Entrez Gene ID: (Human) 3624
ovarian follicle development
mesoderm formation
hair follicle development
hematopoietic progenitor cell differentiation
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
lipid metabolic process
steroid biosynthetic process
autophagy
defense response
cell surface receptor signaling pathway
transmembrane receptor protein serine/threonine kinase signaling pathway
cell-cell signaling
nervous system development
steroid metabolic process
androgen metabolic process
negative regulation of cell proliferation
male gonad development
response to wounding
gene expression
positive regulation of gene expression
cytokine-mediated signaling pathway
striatal medium spiny neuron differentiation
cell differentiation
erythrocyte differentiation
negative regulation of cell growth
negative regulation of interferon-gamma production
activin receptor signaling pathway
positive regulation of collagen biosynthetic process
endodermal cell differentiation
negative regulation of phosphorylation
odontogenesis
hemoglobin biosynthetic process
progesterone secretion
negative regulation of B cell differentiation
positive regulation of erythrocyte differentiation
negative regulation of macrophage differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase III promoter
regulation of follicle-stimulating hormone secretion
positive regulation of follicle-stimulating hormone secretion
negative regulation of follicle-stimulating hormone secretion
mesodermal cell differentiation
cell development
animal organ development
system development
positive regulation of protein metabolic process
Sertoli cell differentiation
palate development
positive regulation of ovulation
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
cardiac fibroblast cell development
eyelid development in camera-type eye
testosterone biosynthetic process
positive regulation of ERK1 and ERK2 cascade
cellular response to follicle-stimulating hormone stimulus
cellular response to cholesterol
cellular response to hypoxia
cellular response to oxygen-glucose deprivation
GABAergic neuron differentiation
extrinsic apoptotic signaling pathway
androst-4-ene-3,17-dione biosynthetic process
response to aldosterone
cellular response to angiotensin
negative regulation of G1/S transition of mitotic cell cycle
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
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