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Invitrogen
Acylated Ghrelin Monoclonal Antibody (891240)
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产品信息
MA5-61918
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
891240
抗原
Human Ghrelin acylated peptide, Gly24-Arg51
偶联物
形式
Lyophilized
浓度
0.5 mg/mL
纯化类型
Protein A/G
保存液
PBS with trehalose
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute at 0.5 mg/mL in sterile PBS.
靶标信息
Acylated ghrelin is a hormone primarily produced by the stomach and released into the bloodstream. It plays a significant role in regulating appetite and energy balance. Functionally, acylated ghrelin acts as an orexigenic hormone, meaning it stimulates appetite and promotes food intake. It interacts with specific receptors in the brain, particularly the growth hormone secretagogue receptor 1a (GHSR1a), to increase hunger signals and enhance food-seeking behaviors. Acylated ghrelin also influences energy homeostasis by increasing fat storage and reducing energy expenditure. Structurally, acylated ghrelin is a peptide hormone consisting of 28 amino acids. It undergoes a post-translational modification process called acylation, where a fatty acid (usually octanoic acid) is attached to the third amino acid residue (serine) in the peptide chain. This acylation is crucial for the hormone's biological activity and stability. Localization-wise, acylated ghrelin is primarily produced by the X/A-like cells in the gastric mucosa. After secretion into the bloodstream, it acts on various target tissues, including the hypothalamus, pituitary gland, and adipose tissue. The hypothalamus is particularly important for regulating appetite and energy balance, as it receives and integrates signals from acylated ghrelin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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