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Adenosine A1 Receptor Polyclonal Antibody

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Adenosine A1 Receptor Polyclonal Antibody

产品信息

AAR-006-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

免疫组化（冰冻） (IHC (F))

Assay-dependent
-

免疫细胞化学 (ICC/IF)

1:100
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)KKVSASSGDPQKYYGKE, corresponding to amino acid residues 213-229 of human A1AR, 3rd intracellular loop
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.85 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: adenosine A1 receptor variant 1; adenosine A1 receptor variant 2; Adenosine receptor A1; ADO-A1 receptor; AR

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基因别名: A1-AR; A1AR; A1R; AA1R; ADORA1; AI848715; BB176431; RDC7; Ri

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UniProt ID: (Human) P30542, (Mouse) Q60612, (Rat) P25099

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Entrez Gene ID: (Human) 134, (Mouse) 11539, (Rat) 29290

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功能
G-protein coupled adenosine receptor activity G-protein coupled receptor binding purine nucleoside binding phospholipase C activity protein binding heat shock protein binding G-protein beta/gamma-subunit complex binding heterotrimeric G-protein binding protein heterodimerization activity signal transducer activity G-protein coupled receptor activity G-protein coupled receptor
参与通路
activation of MAPKK activity temperature homeostasis response to hypoxia adenosine receptor signaling pathway regulation of respiratory gaseous exchange by neurological system process negative regulation of acute inflammatory response negative regulation of leukocyte migration positive regulation of peptide secretion regulation of glomerular filtration protein targeting to membrane phagocytosis inflammatory response signal transduction adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway cell-cell signaling nervous system development negative regulation of cell proliferation negative regulation of glutamate secretion lipid catabolic process negative regulation of synaptic transmission, GABAergic positive regulation of nucleoside transport negative regulation of neurotrophin production positive regulation of protein dephosphorylation negative regulation of renal sodium excretion negative regulation of circadian sleep/wake cycle, non-REM sleep negative regulation of apoptotic process positive regulation of potassium ion transport positive regulation of epidermal growth factor-activated receptor activity negative regulation of blood pressure positive regulation of blood pressure negative regulation of vasodilation negative regulation of hormone secretion cognition detection of temperature stimulus involved in sensory perception of pain negative regulation of lipid catabolic process regulation of sensory perception of pain negative regulation of synaptic transmission, glutamatergic negative regulation of cardiac muscle contraction excitatory postsynaptic potential relaxation of vascular smooth muscle negative regulation of mucus secretion apoptotic signaling pathway negative regulation of long term synaptic depression G-protein coupled receptor signaling pathway negative regulation of circadian sleep/wake cycle, sleep negative regulation of heart contraction regulation of synaptic plasticity negative regulation of inflammatory response regulation of cardiac muscle contraction regulation of vasodilation
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