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Invitrogen
Adipolean (gAcrp30) Polyclonal Antibody, PeproTech®
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Adipolean (gAcrp30) Antibody (500-P193G-1MG) in ELISA
Sandwich ELISA: To detect Human gAcrp30/Adipolean by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of Adipolean (gAcrp30) Polyclonal Antibody (Product # 500-P193G-1MG) is required. This antigen affinity purified antibody, in conjunction with PeproTech Adipolean (gAcrp30) Polyclonal Antibody, Biotin (Product # 500-P193GBT-500UG) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human gAcrp30/Adipolean.
产品信息
500-P193G-1MG
产品规格
种属反应
Human
宿主/亚型
Goat
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived Recombinant Human gAcrp30/Adipolean
偶联物
形式
Lyophilized
浓度
0.1-1.0 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
AA Sequence of recombinant protein: MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN.
Preparation: Produced from sera of goats immunized with highly pure Recombinant Human gAcrp30/Adipolean. Anti-Human gAcrp30/Adipolean-specific antibody was purified by affinity chromatography employing an immobilized Human gAcrp30/Adipolean matrix.
Sandwich ELISA: To detect Human gAcrp30/Adipolean by sandwich ELISA (using 100 µL/well antibody solution) a concentration of 0.5-2.0 µg/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with PeproTech Biotinylated Anti-Human gAcrp30/Adipolean (500-P193GBt) as a detection antibody, allows the detection of at least 0.2-0.4 ng/well of Recombinant Human gAcrp30/Adipolean.
Western Blot: To detect Human gAcrp30/Adipolean by Western Blot analysis this antibody can be used at a concentration of 0.1-0.2 µg/mL. Used in conjunction with compatible secondary reagents the detection limit for Recombinant Human gAcrp30/Adipolean is 1.5-3.0 ng/lane, under either reducing or non-reducing conditions.
靶标信息
gAcrp30 is a naturally occurring globular protein obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and named AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver.
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生物信息学
蛋白别名: 30 kDa adipocyte complement-related protein; ACRP30; Adipocyte complement-related 30 kDa protein; Adipocyte, C1q and collagen domain-containing protein; Adiponectin; Adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; apM-1; gAcrp30; Gelatin-binding protein; gelatin-binding protein 28
基因别名: ACDC; ACRP30; ADIPOQ; ADIPQTL1; ADPN; APM-1; APM1; GBP28
UniProt ID: (Human) Q15848
Entrez Gene ID: (Human) 9370
response to hypoxia
positive regulation of protein phosphorylation
glucose metabolic process
generation of precursor metabolites and energy
fatty acid beta-oxidation
response to nutrient
circadian rhythm
response to sucrose
response to glucose
positive regulation of signal transduction
negative regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of protein kinase A signaling
negative regulation of macrophage derived foam cell differentiation
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of cholesterol efflux
regulation of glucose metabolic process
response to activity
negative regulation of smooth muscle cell migration
fatty acid oxidation
negative regulation of cell migration
negative regulation of granulocyte differentiation
negative regulation of protein autophosphorylation
positive regulation of cellular protein metabolic process
negative regulation of tumor necrosis factor production
positive regulation of interleukin-8 production
cellular response to insulin stimulus
positive regulation of myeloid cell apoptotic process
adiponectin-activated signaling pathway
negative regulation of heterotypic cell-cell adhesion
low-density lipoprotein particle clearance
response to tumor necrosis factor
cellular response to drug
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAP kinase activity
response to ethanol
negative regulation of fat cell differentiation
negative regulation of macrophage differentiation
negative regulation of low-density lipoprotein particle receptor biosynthetic process
negative regulation of gluconeogenesis
negative regulation of blood pressure
positive regulation of blood pressure
negative regulation of transcription, DNA-templated
positive regulation of fatty acid metabolic process
positive regulation of glucose import
negative regulation of hormone secretion
negative regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of phagocytosis
negative regulation of synaptic transmission
brown fat cell differentiation
protein homooligomerization
response to glucocorticoid
membrane depolarization
membrane hyperpolarization
protein heterotrimerization
negative regulation of ERK1 and ERK2 cascade
response to linoleic acid
detection of oxidative stress
cellular response to cAMP
positive regulation of monocyte chemotactic protein-1 production
cellular response to epinephrine stimulus
protein localization to plasma membrane
negative regulation of intracellular protein transport
negative regulation of receptor binding
negative regulation of DNA biosynthetic process
positive regulation of glycogen (starch) synthase activity
positive regulation of metanephric glomerular visceral epithelial cell development
positive regulation of cAMP-dependent protein kinase activity
positive regulation of renal albumin absorption
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
negative regulation of metanephric mesenchymal cell migration
