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Fabgennix

Adiponectin Polyclonal Antibody

查看其他33个Adiponectin抗体

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说明书
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说明书
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实验方案
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说明书
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产品信息

ADPN-101AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化 (IHC)

1:50-1:250
-

酶联免疫吸附实验 (ELISA)

1:10,000
-

免疫沉淀 (IP)

1:50-1:250
-
产品规格

种属反应

Human, Mouse, Pig

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 150-250 on pig Adiponectin protein.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 30 kDa adipocyte complement related protein; 30 kDa adipocyte complement-related protein; ACRP30; adipocyte complement related protein; Adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ; adipocytokine; Adiponectin; Adipose most abundant gene transcript 1 protein; ADN; ADPIOQ; apM-1; Gelatin-binding protein

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基因别名: 30kDa; ACDC; ACRP30; Ad; adipo; ADIPOQ; ADN; APM1; APN; GBP28

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UniProt ID: (Mouse) Q60994

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Entrez Gene ID: (Pig) 397660, (Mouse) 11450

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功能
receptor binding hormone activity protein binding sialic acid binding identical protein binding protein homodimerization activity
参与通路
positive regulation of protein phosphorylation glucose metabolic process fatty acid beta-oxidation response to glucose positive regulation of signal transduction negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of protein kinase A signaling negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process negative regulation of smooth muscle cell migration fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation negative regulation of protein autophosphorylation positive regulation of cellular protein metabolic process negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus positive regulation of myeloid cell apoptotic process adiponectin-activated signaling pathway negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor cellular response to drug glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of low-density lipoprotein particle receptor biosynthetic process negative regulation of gluconeogenesis negative regulation of blood pressure positive regulation of blood pressure positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of hormone secretion negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation protein homooligomerization membrane depolarization membrane hyperpolarization protein heterotrimerization negative regulation of ERK1 and ERK2 cascade detection of oxidative stress cellular response to cAMP positive regulation of monocyte chemotactic protein-1 production cellular response to epinephrine stimulus protein localization to plasma membrane negative regulation of intracellular protein transport negative regulation of receptor binding negative regulation of DNA biosynthetic process positive regulation of glycogen (starch) synthase activity positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of cAMP-dependent protein kinase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration
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