Invitrogen

Adiponectin Recombinant Rabbit Monoclonal Antibody (8H25L59)

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Adiponectin Recombinant Rabbit Monoclonal Antibody (8H25L59)

产品信息

704917

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化（石蜡） (IHC (P))

1:500
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

Expi293

分类

Recombinant Monoclonal

类型

Antibody

克隆号

8H25L59

抗原

Protein corresponding to human Adiponectin [aa19-aa244]
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.0 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_3699320

产品详细信息

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include better specificity and lot-to-lot consistency.

It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

靶标信息

Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 30 kDa adipocyte complement-related protein; ACRP30; adipocyte complement related protein; adipocyte complement related protein of 30 kDa; Adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ; Adiponectin; Adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADPIOQ; apM-1; Gelatin-binding protein; gelatin-binding protein 28

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基因别名: 30kDa; ACDC; ACRP30; Ad; adipo; ADIPOQ; ADIPQTL1; ADPN; APM-1; APM1; APN; GBP28

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UniProt ID: (Human) Q15848, (Mouse) Q60994

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Entrez Gene ID: (Human) 9370, (Rat) 246253, (Mouse) 11450

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功能
receptor binding cytokine activity hormone activity protein binding sialic acid binding identical protein binding protein homodimerization activity
参与通路
response to hypoxia positive regulation of protein phosphorylation glucose metabolic process fatty acid beta-oxidation response to nutrient circadian rhythm response to sucrose response to glucose positive regulation of signal transduction negative regulation of platelet-derived growth factor receptor signaling pathway positive regulation of protein kinase A signaling negative regulation of macrophage derived foam cell differentiation negative regulation of tumor necrosis factor-mediated signaling pathway positive regulation of cholesterol efflux regulation of glucose metabolic process response to activity negative regulation of smooth muscle cell migration fatty acid oxidation negative regulation of cell migration negative regulation of granulocyte differentiation response to nutrient levels negative regulation of protein autophosphorylation positive regulation of cellular protein metabolic process negative regulation of tumor necrosis factor production positive regulation of interleukin-8 production cellular response to insulin stimulus positive regulation of myeloid cell apoptotic process adiponectin-activated signaling pathway negative regulation of heterotypic cell-cell adhesion low-density lipoprotein particle clearance response to tumor necrosis factor cellular response to drug response to drug glucose homeostasis positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAP kinase activity response to ethanol negative regulation of fat cell differentiation negative regulation of macrophage differentiation negative regulation of low-density lipoprotein particle receptor biosynthetic process negative regulation of gluconeogenesis negative regulation of blood pressure positive regulation of blood pressure positive regulation of protein kinase activity negative regulation of transcription, DNA-templated positive regulation of fatty acid metabolic process positive regulation of glucose import negative regulation of hormone secretion negative regulation of smooth muscle cell proliferation negative regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation negative regulation of phagocytosis negative regulation of synaptic transmission brown fat cell differentiation protein homooligomerization response to glucocorticoid membrane depolarization membrane hyperpolarization protein heterotrimerization negative regulation of ERK1 and ERK2 cascade response to linoleic acid detection of oxidative stress cellular response to cAMP positive regulation of monocyte chemotactic protein-1 production cellular response to epinephrine stimulus protein localization to plasma membrane negative regulation of intracellular protein transport negative regulation of receptor binding negative regulation of DNA biosynthetic process positive regulation of glycogen (starch) synthase activity positive regulation of metanephric glomerular visceral epithelial cell development positive regulation of cAMP-dependent protein kinase activity positive regulation of renal albumin absorption negative regulation of platelet-derived growth factor receptor-alpha signaling pathway negative regulation of metanephric mesenchymal cell migration generation of precursor metabolites and energy
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