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Invitrogen
Afadin Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-105733
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human AFDN(Accession P55196), corresponding to amino acid residues L1205-K1255.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total Afadin.
靶标信息
AFDN belongs to an adhesion system, probably together with the E-cadherin-catenin system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). Nectin- and actin-filament-binding protein that connects nectin to the actin cytoskeleton.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ALL-1 fusion partner from chromosome 6; ALL1-fused gene from chromosome 6 protein; F-actin binding protein; FLJ34371; fusion gene; large splicing variant of AF-6 protein; myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4; protein AF-6; RP3-431P23.3; RP3-470B24.4; small splicing variant of l-Afadin; translocated to, 4; unnamed protein product
基因别名: 5033403D15Rik; Af-6; AF6; Afadin; Gm314; I-afadin; l-afadin; MLL-AF6; MLLT4; S-afadin
UniProt ID: (Human) P55196, (Mouse) Q9QZQ1, (Rat) O35889
Entrez Gene ID: (Human) 4301, (Mouse) 17356, (Rat) 26955
signal transduction
positive regulation of gene expression
telencephalon development
cerebral cortex development
positive regulation of cell-cell adhesion
cell differentiation
negative regulation of cell migration
cell junction organization
adherens junction maintenance
cell-cell adhesion mediated by cadherin
pore complex assembly
brain morphogenesis
homeostasis of number of cells
positive regulation of dendrite morphogenesis
radial glial cell differentiation
neuroepithelial cell differentiation
positive regulation of dendritic spine morphogenesis
positive regulation of mini excitatory postsynaptic potential
establishment of protein localization to plasma membrane
regulation of oligodendrocyte progenitor proliferation
bicellular tight junction assembly
establishment of endothelial intestinal barrier
postsynaptic specialization organization
regulation of postsynapse organization
dendrite arborization
regulation of postsynapse assembly
protein localization to cell junction
positive regulation of dendrite extension
positive regulation of cell-cell adhesion mediated by cadherin
cell adhesion
cell-cell signaling
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