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Invitrogen
Aletekutug Humanized Recombinant Human Monoclonal Antibody
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产品信息
MA5-58331
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Human
/ IgG1
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Protein A
保存液
25mM histidine, pH 6.2, with 8% sucrose, 0.01% Tween 80
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
RRID
产品详细信息
For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °.
靶标信息
Interleukin-18 (IL-18) is a cytokine belonging to the IL-1 family and is initially synthesized as an inactive precursor, pro-IL-18. This precursor undergoes proteolytic processing by caspase-1, leading to the production of mature IL-18. Structurally, mature IL-18 forms a complex with its receptor IL-18R alpha and, along with the accessory protein IL-18R beta, initiates a signaling cascade. Functionally, IL-18 plays a crucial role in both innate and adaptive immunity by inducing the production of interferon-gamma (IFN-gamma), particularly in concert with IL-12, which activates natural killer (NK) cells and promotes Th1 cell responses. Additionally, IL-18 can influence Th2 and IL-17-producing gamma delta T cells, macrophage activation, and inflammatory responses, underscoring its multifaceted role in immune regulation and disease pathogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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