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Alpha 2 Na+/K+ ATPase Polyclonal Antibody

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说明书
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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
Alpha 2 Na+/K+ ATPase Polyclonal Antibody

产品信息

ANP-002-200UL

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:200
-

免疫组化（冰冻） (IHC (F))

1:300
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)REYSPAATTAENG, corresponding to amino acid residues 7-19 of rat ATP1A2, Intracellular, N-terminus
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

靶标信息

Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Sodium Potassium ATPase; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-2; sodium/potassium-transporting ATPase alpha-2 chain; Sodium/potassium-transporting ATPase subunit alpha-2

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基因别名: ATP1A2; Atpa-3; AW060654; FHM2; KIAA0778; MHP2; mKIAA0778; RATATPA2

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UniProt ID: (Human) P50993, (Rat) P06686, (Mouse) Q6PIE5

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Entrez Gene ID: (Human) 477, (Rat) 24212, (Mouse) 98660

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功能
sodium:potassium-exchanging ATPase activity protein binding ATP binding drug binding ATPase activity potassium ion binding sodium ion binding chaperone binding steroid hormone binding cation-transporting ATPase activity metal ion binding nucleotide binding hydrolase activity primary active transporter
参与通路
neurotransmitter uptake regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process potassium ion transport sodium ion transport cellular sodium ion homeostasis regulation of smooth muscle contraction regulation of striated muscle contraction regulation of blood pressure adult locomotory behavior visual learning potassium ion import establishment or maintenance of transmembrane electrochemical gradient regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ATP hydrolysis coupled proton transport regulation of vasoconstriction cellular potassium ion homeostasis ion transmembrane transport response to nicotine sodium ion export from cell locomotion negative regulation of heart contraction negative regulation of striated muscle contraction ATP metabolic process negative regulation of cytosolic calcium ion concentration regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic relaxation of cardiac muscle cardiac muscle contraction cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization membrane depolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction negative regulation of calcium ion transmembrane transport negative regulation of calcium:sodium antiporter activity response to glycoside regulation of cardiac conduction potassium ion import across plasma membrane regulation of muscle contraction metabolic process regulation of cardiac muscle contraction by calcium ion signaling energy coupled proton transmembrane transport, against electrochemical gradient transport ion transport
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