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Invitrogen
Amantadine Recombinant Mouse Monoclonal Antibody (6G1)
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Amantadine Antibody (MA566642) in SDS-PAGE
SDS-PAGE characterization of Amantadine under reducing conditions. Lane M: Protein marker (kDa); Lane AMS: Purified Amantadine Recombinant Monoclonal (Product # MA566642). Amantadine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-386.
产品信息
MA566642
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
6G1
抗原
Conjugate of AMS hapten and KLH.
偶联物
形式
Liquid
浓度
7.1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Amantadine is a well-established antiviral and antiparkinsonian agent, primarily targeting the NMDA receptor to exert its therapeutic effects. It is located on chromosome 1 at the locus 1p36.23, and its chemical structure is characterized by a tricyclic amine with a cage-like adamantane core, which contributes to its unique pharmacokinetic properties. Functionally, amantadine blocks viral replication by interfering with the viral M2 protein, and in Parkinson's disease, it modulates dopaminergic transmission, providing symptomatic relief. Recent studies have explored its hybridization with gardenamide A to enhance NMDA antagonism, indicating potential for expanded therapeutic applications. The development of biosimilar versions aims to improve accessibility and reduce costs associated with amantadine therapy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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