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Working Concentration: 2.5 µg/mL. Sensitivity: 10 ng/mL Amitriptyline produces 67% inhibition in a competitive ELISA employing Tricyclic Antidepressants (TCA) (1) polyclonal antibody.
Amitriptyline is a Tricyclic Antidepressant that inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity. [National Center for Biotechnology Information. PubChem Compound Database; CID=2160].
仅用于科研。不用于诊断过程。未经明确授权不得转售。