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Invitrogen
Amlodipine Recombinant Mouse Monoclonal Antibody (1B2)
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Amlodipine Antibody (MA566637) in SDS-PAGE
SDS-PAGE characterization of Amlodipine under reducing conditions. Lane M: Protein marker (kDa); Lane ADP: Purified Amlodipine Recombinant Monoclonal (Product # MA566637). Amlodipine showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-628.
产品信息
MA566637
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
1B2
抗原
Conjugate of ADP hapten and KLH.
偶联物
形式
Liquid
浓度
9.2 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Amlodipine is a long-acting dihydropyridine calcium channel blocker widely prescribed for the management of hypertension and angina pectoris. Structurally, amlodipine comprises a dihydropyridine core that facilitates its mechanism of action by inhibiting calcium ion influx through L-type calcium channels in vascular smooth muscle cells, leading to vasodilation and decreased peripheral resistance. This action effectively lowers blood pressure and reduces myocardial oxygen demand, helping to alleviate symptoms of angina. Amlodipine's pharmacokinetics are characterized by slow absorption and prolonged half-life, providing sustained therapeutic effects and permitting once-daily dosing. It is generally well-tolerated, with potential side effects including headache and peripheral edema. Research into amlodipine continues to explore its benefits in combination therapies for cardiovascular disease management, as well as its applications in treating related conditions such as coronary artery disease and certain types of heart failure.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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