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Invitrogen
Angiogenin Polyclonal Antibody
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产品信息
PA5-139827
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: QDNSRYTHFL TQHYDAKPQG RDDRYCESIM RRRGLTSPCK DINTFIHGNK RSIKAICENK NGN
Highest antigen sequence indentity to the following orthologs: Rat - 73%, Mouse - 73%.
靶标信息
Angiogenin (ANG or ANG I) is important for the process of neovascularization and formation of new blood vessels. ANG is similar to pancreatic ribonuclease A and functions as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. It interacts with endothelial cell-surface actin and may cause changes in the cell cytoskeleton. ANG is thought to be involved in the development of solid tumors and its antagonists are capable of inhibiting tumor growth. Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9). Angiogenin is a genetic link between ALS and PD.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Angiogenin; angiogenin, ribonuclease, RNase A family, 5; epididymis luminal protein 168; MGC22466; MGC71966; Ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5; RNase 5
基因别名: ALS9; ANG; HEL168; RAA1; RNASE4; RNASE5
UniProt ID: (Human) P03950
Entrez Gene ID: (Human) 283
angiogenesis
ovarian follicle development
oocyte maturation
response to hypoxia
response to yeast
placenta development
positive regulation of endothelial cell proliferation
diacylglycerol biosynthetic process
cell communication
activation of phospholipase C activity
rRNA transcription
response to hormone
cell migration
negative regulation of translation
antibacterial humoral response
antifungal humoral response
actin filament polymerization
activation of protein kinase B activity
activation of phospholipase A2 activity
adherens junction organization
positive regulation of phosphorylation
homeostatic process
innate immune response
negative regulation of smooth muscle cell proliferation
positive regulation of protein secretion
defense response to Gram-positive bacterium
RNA phosphodiester bond hydrolysis
