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Angiotensin I through VII are bioactive peptides that form part of the reninangiotensin system (RAS), integral to regulating cardiovascular, renal, and fluid electrolytes. Angiotensin I, an inactive precursor, is converted into Angiotensin II, a potent vasoconstrictor, which in turn can be further processed into smaller peptides, such as Angiotensin III, IV, and Angiotensin(17). Angiotensin(17) is particularly noteworthy for its beneficial roles in countering the effects of Angiotensin II; it acts via the Mas receptor and is known for its protective effects against vascular aging. It reduces inflammation, oxidative stress, and modulates pathways related to prostaglandin, bradykinin, and nitric oxide. These peptides play diverse roles in maintaining blood pressure and hydroelectrolyte balance, alongside influencing cardiac and vascular functions. Research continues to elucidate the distinct physiological roles of each peptide, particularly the interplay between the traditional angiotensin pathways and the more recently understood actions mediated by angiotensin(17).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ACE-related carboxypeptidase; ACEH; alpha-1 antiproteinase, antitrypsin; Angiotensin 1-7; angiotensin I; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; Angiotensin I-VII; angiotensin II; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Angiotensinogen; angiotensinogen (PAT); angiotensinogen (serpin peptidase inhibitor, clade A, member 8); anigotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A; pre-angiotensinogen; renal angiotensin-converting enzyme 2; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8
基因别名: ACE2; ACEH; AGT; Ang; AngII; ANHU; ANRT; PAT; SERPINA8; UNQ868/PRO1885
UniProt ID: (Human) Q9BYF1, (Human) P01019, (Rat) Q5EGZ1, (Rat) P01015
Entrez Gene ID: (Human) 59272, (Human) 183, (Rat) 302668, (Rat) 24179