Invitrogen

Angiotensinogen Recombinant Rabbit Monoclonal Antibody (034)

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Angiotensinogen Recombinant Rabbit Monoclonal Antibody (034)

产品信息

MA5-29010

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500
-

免疫组化 (IHC)

-
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免疫组化（石蜡） (IHC (P))

1:100-1:500
-

免疫细胞化学 (ICC/IF)

1:200
-
产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

034

抗原

Recombinant Human SerpinA8/Angiotensinogen/AGT protein (Met1-Ala485)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS

内含物

no preservative

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2784948

产品详细信息

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

This antibody has specificity for Human SerpinA8/Angiotensinogen/AGT.

靶标信息

The protein encoded by AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: alpha-1 antiproteinase, antitrypsin; angiotensin I; angiotensin II; Angiotensinogen; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); pre-angiotensinogen; serine (or cysteine) proteinase inhibitor; Serpin A8; serpin peptidase inhibitor, clade A, member 8

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基因别名: AGT; ANHU; SERPINA8

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UniProt ID: (Human) P01019

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Entrez Gene ID: (Human) 183

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功能
serine-type endopeptidase inhibitor activity hormone activity protein binding growth factor activity type 1 angiotensin receptor binding type 2 angiotensin receptor binding protease inhibitor
参与通路
regulation of cell growth positive regulation of cytokine production kidney development blood vessel remodeling angiotensin maturation regulation of blood volume by renin-angiotensin renin-angiotensin regulation of aldosterone production regulation of renal output by angiotensin regulation of heart rate regulation of blood vessel size by renin-angiotensin renal system process angiotensin-mediated drinking behavior positive regulation of extracellular matrix constituent secretion cellular sodium ion homeostasis cell surface receptor signaling pathway G-protein coupled receptor signaling pathway G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger phospholipase C-activating G-protein coupled receptor signaling pathway activation of phospholipase C activity nitric oxide mediated signal transduction cell-cell signaling female pregnancy aging regulation of blood pressure positive regulation of activation of JAK2 kinase activity positive regulation of endothelial cell migration positive regulation of cardiac muscle hypertrophy positive regulation of macrophage derived foam cell differentiation positive regulation of cholesterol esterification negative regulation of endopeptidase activity regulation of norepinephrine secretion positive regulation of phosphatidylinositol 3-kinase signaling artery smooth muscle contraction response to muscle activity involved in regulation of muscle adaptation negative regulation of angiogenesis regulation of vasoconstriction negative regulation of cell growth positive regulation of cellular protein metabolic process positive regulation of superoxide anion generation positive regulation of NAD(P)H oxidase activity negative regulation of tissue remodeling low-density lipoprotein particle remodeling catenin import into nucleus regulation of renal sodium excretion positive regulation of renal sodium excretion regulation of cell proliferation vasodilation positive regulation of nitric oxide biosynthetic process positive regulation of epidermal growth factor receptor signaling pathway positive regulation of blood pressure positive regulation of transcription, DNA-templated positive regulation of vasodilation fibroblast proliferation positive regulation of fibroblast proliferation regulation of long-term neuronal synaptic plasticity smooth muscle cell proliferation cytokine secretion positive regulation of inflammatory response positive regulation of peptidyl-tyrosine phosphorylation positive regulation of NF-kappaB transcription factor activity negative regulation of neurotrophin TRK receptor signaling pathway stress-activated MAPK cascade regulation of calcium ion transport regulation of transmission of nerve impulse cell growth involved in cardiac muscle cell development positive regulation of protein tyrosine kinase activity ERK1 and ERK2 cascade uterine smooth muscle contraction cellular response to mechanical stimulus positive regulation of branching involved in ureteric bud morphogenesis regulation of extracellular matrix assembly positive regulation of gap junction assembly regulation of cardiac conduction positive regulation of reactive oxygen species metabolic process positive regulation of extrinsic apoptotic signaling pathway
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