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Invitrogen
Ankyrin G Polyclonal Antibody
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产品信息
PA5-83418
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human ANK3
偶联物
形式
Liquid
浓度
0.20 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ENNVFHDPVD GWQNETSSGN LESCAQARRV TGGLLDRLDD SPDQCRDSIT SYLKGEAGKF EANGSHTEIT PEAKTKSYFP ESQNDVGKQ
Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 83%.
靶标信息
Ankyrin-G is found in several tissues including brain where, due to tissue-specific RNA processing, it is expressed as two different isoforms, localized to axon initial segments and nodes of Ranvier. Ankyrin-G is also found at sites of epithelial cell-cell contact and in the intracellular membranes of some cells. Ankyrin-G isoforms contain a unique stretch of sequence highly enriched in serine and threonine residues immediately following a globular head domain. Ankyrin-G is thought to participate in the maintenance and targeting of ion channels and cell adhesion molecules to the nodes of Ranvier and to axon initial segments.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ANK-3; Ankyrin-3; Ankyrin-G
基因别名: ANK3; ANKYRIN-G; MRT37
UniProt ID: (Human) Q12955
Entrez Gene ID: (Human) 288
mitotic cytokinesis
ER to Golgi vesicle-mediated transport
plasma membrane organization
cytoskeletal anchoring at plasma membrane
signal transduction
axonogenesis
axon guidance
neuromuscular junction development
positive regulation of gene expression
positive regulation of cell communication by electrical coupling
positive regulation of sodium ion transport
magnesium ion homeostasis
neuronal action potential
positive regulation of homotypic cell-cell adhesion
Golgi to plasma membrane protein transport
regulation of potassium ion transport
establishment of protein localization
positive regulation of membrane potential
cellular response to magnesium ion
membrane assembly
protein localization to plasma membrane
maintenance of protein location in plasma membrane
protein targeting to plasma membrane
positive regulation of protein targeting to membrane
positive regulation of membrane depolarization during cardiac muscle cell action potential
negative regulation of delayed rectifier potassium channel activity
positive regulation of sodium ion transmembrane transporter activity
positive regulation of cation channel activity
