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ApoC3 Antibody (MA5-42767) in IHC (P)
Immunohistochemistry analysis of ApoC3 in paraffin-embedded human liver. Samples were incubated with ApoC3 Monoclonal antibody (Product # MA5-42767) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-42767
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
3T7Y5
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-99 of human Apolipoprotein C3 (P02656).
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2911908
产品详细信息
Positive test controls include: Human plasma.
Immunogen sequence: MQPRVLLVVA LLALLASARA SEAEDASLLS FMQGYMKHAT KTAKDALSSV QESQVAQQAR GWVTDGFSSL KDYWSTVKDK FSEFWDLDPE VRPTSAVAA
靶标信息
Apolipoprotein C-III, also known as apo-CIII, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is a component of very low density lipoprotein (VLDL). APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apo-CIII; apoC-III; Apolipoprotein; Apolipoprotein C-III; Apolipoprotein C3; MGC150353
基因别名: apo-CIII; apoC-III; APOC3; APOCIII; HALP2
UniProt ID: (Human) P02656, (Mouse) P33622
Entrez Gene ID: (Human) 345, (Mouse) 11814
retinoid metabolic process
triglyceride metabolic process
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of triglyceride biosynthetic process
negative regulation of triglyceride catabolic process
negative regulation of very-low-density lipoprotein particle remodeling
negative regulation of very-low-density lipoprotein particle clearance
negative regulation of high-density lipoprotein particle clearance
negative regulation of low-density lipoprotein particle clearance
triglyceride catabolic process
regulation of Cdc42 protein signal transduction
response to vitamin A
cholesterol efflux
phospholipid efflux
response to triglyceride
high-density lipoprotein particle remodeling
very-low-density lipoprotein particle assembly
chylomicron remnant clearance
lipoprotein metabolic process
response to drug
cholesterol homeostasis
lipoprotein transport
response to peptide hormone
reverse cholesterol transport
negative regulation of fatty acid biosynthetic process
negative regulation of lipid metabolic process
negative regulation of receptor-mediated endocytosis
negative regulation of lipid catabolic process
negative regulation of lipoprotein lipase activity
negative regulation of cholesterol import
triglyceride homeostasis
response to fatty acid
cellular response to glucose stimulus
negative regulation of oxidative phosphorylation
response to simvastatin
lipid metabolic process
triglyceride mobilization
transport
lipid transport
cholesterol metabolic process
lipid catabolic process
