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Invitrogen
Apoptosis-Enhancing Nuclease Polyclonal Antibody
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产品信息
PA5-111279
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.05 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SLTIPNAKDV LRKRHKRRSR QHQRFMARKA LLQEQGLLSM PPEPGSSPLP TPFGAATATE AASSGKQCLR AGSGSAP
Highest antigen sequence indentity to the following orthologs: Rat - 62%, Mouse - 62%.
靶标信息
Apoptosis-Enhancing Nuclease (AEN) is a nuclear exonuclease that serves as a critical player in p53-mediated apoptosis. Induced by p53 in response to various DNA damage signals, AEN is involved in the degradation of cellular DNA during apoptosis. The nuclease activity of AEN contributes to the controlled dismantling of cellular components, ensuring that the apoptotic process leads to the efficient and timely removal of damaged or unwanted cells. Its expression regulation via phosphorylation highlights the intricacy of apoptotic signaling pathways and underscores the importance of AEN in maintaining genomic stability and preventing tumorigenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Apoptosis-enhancing nuclease; interferon stimulated exonuclease gene 20kDa-like 1; Interferon-stimulated 20 kDa exonuclease-like 1
基因别名: AEN; ISG20L1; pp12744; SBBI58
UniProt ID: (Human) Q8WTP8
Entrez Gene ID: (Human) 64782
