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Invitrogen
Arginase 1 Monoclonal Antibody (C7)
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Arginase 1 Antibody (MA5-50871) in ICC/IF
Immunocytochemistry analysis of Arginase 1 in HepG2 cells. Samples were incubated with Arginase 1 monoclonal antibody (Product # MA5-50871) using a dilution of 40 µg/mL followed by FITC-Linked Caprine Anti-Mouse IgG secondary antibody at a dilution of 1 µg/mL.
产品信息
MA5-50871
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Pig
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
C7
抗原
Recombinant Human ARG protein, Met1-Lys322 (Accession #P05089)
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% Proclin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
靶标信息
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: A-I; Arginase; arginase 1 liver; arginase I; arginase, liver; Arginase-1; Arginase1; HGNC:663; Liver Arginase; Liver-type arginase; Type 1 Arginase; Type I arginase
基因别名: ARG1
UniProt ID: (Pig) Q95JC8, (Human) P05089
Entrez Gene ID: (Pig) 397115, (Human) 383
urea cycle
defense response to protozoan
negative regulation of activated T cell proliferation
negative regulation of interferon-gamma-mediated signaling pathway
positive regulation of neutrophil mediated killing of fungus
negative regulation of T-helper 2 cell cytokine production
liver development
positive regulation of endothelial cell proliferation
arginine catabolic process
aging
response to herbicide
response to manganese ion
response to zinc ion
response to selenium ion
regulation of L-arginine import
response to amine
arginine catabolic process to ornithine
lung development
collagen biosynthetic process
response to vitamin A
response to vitamin E
response to drug
response to amino acid
response to cadmium ion
response to axon injury
response to methylmercury
mammary gland involution
maternal process involved in female pregnancy
protein homotrimerization
cellular response to hydrogen peroxide
cellular response to lipopolysaccharide
cellular response to interleukin-4
cellular response to glucagon stimulus
cellular response to dexamethasone stimulus
cellular response to transforming growth factor beta stimulus
