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Invitrogen
Aristolochic acids Recombinant Mouse Monoclonal Antibody (2A8)
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Aristolochic acids Antibody (MA566633) in SDS-PAGE
SDS-PAGE characterization of Aristolochic acids under reducing conditions. Lane M: Protein marker (kDa); Lane AAS: Purified Aristolochic acids Recombinant Monoclonal (Product # MA566633). Aristolochic acids showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-269.
产品信息
MA566633
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
2A8
抗原
Conjugate of AAS hapten and KLH.
偶联物
形式
Liquid
浓度
3.4 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Aristolochic acids are a group of structurally related nitrophenanthrene carboxylic acid derivatives found naturally in the Aristolochiaceae plant family, traditionally used in herbal medicines. The distinctive structure includes a phenanthrene core with a nitro group, which contributes to their highly toxic and carcinogenic properties. Aristolochic acids are known to form DNA adducts, leading to mutations and promoting tumorigenesis, which is linked to urothelial cancer and nephropathy known as Aristolochic Acid Nephropathy (AAN). Due to their genotoxic effects, the use of plants containing these compounds has been heavily scrutinized, resulting in regulatory actions to limit exposure and ensure consumer safety. Despite their historical use for various ailments, research underscores the critical need to understand the mechanisms of toxicity and implement stringent controls in herbal product manufacturing to prevent adverse health outcomes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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