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Antibodies Inc
Ataxin-1/11NQ Monoclonal Antibody (N76/3)
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产品信息
75-122
应用
建议稀释比
已发表文章
产品规格
种属反应
Fruit fly,
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
N76/3
抗原
Synthetic peptide amino acids 164-197 of mouse ataxin-1 (accession number P54254).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4
内含物
0.065% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
For maximum recovery of product, centrifuge the vial prior to removing the cap.
Sequence of this protein is as follows: ATTPSQRSQL EAYSTLLANM GSLSQAPGHK VEPP
靶标信息
Ataxin-1 (11NQ) refers to a specific isoform or variant of the Ataxin-1 protein, characterized by having 11 normal glutamine (Q) residues in its polyglutamine (polyQ) tract. This is in contrast to the expanded polyQ tracts found in disease-causing variants associated with spinocerebellar ataxia type 1 (SCA1). Ataxin-1 (11NQ) serves as a model for studying the normal physiological roles of Ataxin-1 and provides a contrast to the pathogenic forms associated with neurodegenerative diseases, enhancing our understanding of protein misfolding and aggregation disorders.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alternative ataxin1; Ataxin-1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog; Spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
基因别名: 2900016G23Rik; ATX1; ATXN1; C85907; D6S504E; ENSMUSG00000074917; Gm10786; SCA1
UniProt ID: (Human) P54253, (Mouse) P54254, (Rat) Q63540
Entrez Gene ID: (Human) 6310, (Mouse) 20238, (Rat) 25049
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
adult locomotory behavior
visual learning
negative regulation of phosphorylation
negative regulation of insulin-like growth factor receptor signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
lung alveolus development
nuclear export
excitatory postsynaptic potential
positive regulation of glial cell proliferation
RNA processing
biological_process
